Val-Cit-PAB-MMAE is a precursor of an antibody-drug conjugate for ADC that contains an ADC linker (peptide Val-Cit-PAB) and a cytotoxic payload MMAE. It can attach to monoclonal antibodies (MABs), directing them to cancer cells. Monomethyl Auristatin E(MMAE) acts as a potent mitotic inhibitor by inhibiting tubulin polymerization. Valine-citrulline is a common lysosomal cleavable dipeptide. PAB is a typical self-immolation spacer.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.