Mal-PEG8-Val-Cit-PAB-MMAE CAS:2353409-69-3 is a sophisticated drug-linker molecule, comprising a maleimide functional group (Mal), polyethylene glycol (PEG8) spacer, valine-citrulline (Val-Cit) dipeptide, para-aminobenzyl (PAB) carbamate, and monomethyl auristatin E (MMAE) cytotoxin. The functional group enables site-specific conjugation, enhanced solubility, and controlled drug release, elevating the therapeutic potential of antibody-drug conjugates (ADCs).
Introduction to the application:
In pharmaceutical research and development, Mal-PEG8-Val-Cit-PAB-MMAE plays a crucial role in designing ADCs for targeted cancer therapy. The drug-linker complex enables precise delivery of the potent MMAE cytotoxin to cancer cells, minimizing off-target effects and improving treatment efficacy. The innovative Val-Cit dipeptide linker ensures stability in the bloodstream and selective release within tumor cells, contributing to the development of safer, more effective anticancer therapeutics.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.