Fmoc-Val-Ala-PAB-PNP, Fmoc-Val-Ala-PABc-PNP
CAS: 1394238-92-6
Description:
Fmoc-Val-Ala-PAB-PNP is a peptide reagent featuring an Fmoc-protected valine-alanine dipeptide linked to a p-aminobenzyl alcohol p-nitrophenyl carbonate (PAB-PNP) group. The Fmoc group protects the N-terminal amine during peptide synthesis, while the PAB-PNP group enables the release of active molecules upon cleavage. This compound is used in drug delivery systems, bioconjugation, and peptide synthesis, particularly for targeted drug delivery in antibody-drug conjugates (ADCs).
Key Features:
- Fmoc Protection: Shields the N-terminal amine during peptide synthesis, ensuring controlled peptide elongation.
- PAB-PNP Group: A cleavable linker that facilitates the release of active molecules, ideal for targeted drug delivery.
- Val-Ala Linker: Designed for cathepsin b cleavage, enabling specific release of the payload in targeted ADCs (antibody-drug conjugates).
- Stable Dipeptide: Val-Ala serves as a stable and efficient linker for constructing peptide-based drug conjugates.
Applications:
- Drug Delivery Systems: Used in the creation of prodrugs or peptide-drug conjugates for controlled, targeted release, particularly in ADCs.
- Bioconjugation: Facilitates the attachment of therapeutic agents to peptides or proteins for selective delivery.
- Peptide Synthesis: Acts as a building block in peptide synthesis, especially for the design of drug conjugates and biomolecular modifications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
