Peptide Linkers

Enzymatically cleavable peptide linkers have gained significant attention in ADC development. They offer superior plasma stability and target specific release mechanism.

Val-Cit and Phe-Lys are optimized peptide-based linkers that can be cleaved by lysosomal extracts and human cathepsin B. Val-Cit (vc) has been successfully implemented in ADCs with payloads such as MMAE/MMAF. Bifunctional p-aminobenzyl alcohol group (PAB) has been used to separate drugs from the site of enzymatic cleavage and minimize the influence of the drug structure and cytotoxic activity. Glutamic acid–valine–citrulline linkers have been reported to ensure in vivo stability and efficacy of antibody–drug conjugates.

AxisPharm has successfully developed technology to produced a series of peptide linkers, such as Fmoc-Val-Cit-PAB, Fmoc-Phe-Lys(Trt)-PAB, Fmoc-Ala-Ala-Asn(Trt)-PAB-PNP, Fmoc-Ala-Ala-Asn-PAB-PNP, and Glutamic acid–valine–citrulline linkers, etc. from gram to kilogram scale in high quality. Our customized ADC conjugation service helps our clients design and select the most suitable linker based on efficacy and toxicity requirement of individual ADCs, all with the best quality and in an cost-effective way.

For inquiries, please call us at: 858-677-9432. or email us at: info@axispharm.com

Catalog No. Name Structure M.W. Purity Pricing
AP10005 Boc-Val-Cit Boc-Val-Cit 374.4 95% Pricing

AP10005

Boc-Val-Cit
Unit Price(USD) Quantity
100mg $70.00
250mg $120.00
1g $240.00
5g $710.00
AP10006 Boc-Val-Cit-PAB Boc-Val-Cit-PAB 479,59 95% Pricing

AP10006

Boc-Val-Cit-PAB
Unit Price(USD) Quantity
100mg $140.00
250mg $280.00
500mg $480.00
1g $740.00
AP10021 Boc-Val-Cit-PAB-PNB Boc-Val-Cit-PAB-PNB 644.67 95% Pricing

AP10021

Boc-Val-Cit-PAB-PNB
Unit Price(USD) Quantity
100mg $200.00
250mg $310.00
500mg $540.00
1g $850.00
AP10747 DBCO-PEG4 acetic -EVCit-PAB DBCO-PEG4 acetic -EVCit-PAB 1041.21 95% Pricing

AP10747

DBCO-PEG4 acetic -EVCit-PAB
Unit Price(USD) Quantity
50mg $1,980.00
100mg $2,970.00
AP10750 DBCO-PEG4-acetic-Val-Cit-PAB DBCO-PEG4-acetic-Val-Cit-PAB 855.99 95% Pricing

AP10750

DBCO-PEG4-acetic-Val-Cit-PAB
Unit Price(USD) Quantity
50mg $790.00
100mg $1,180.00
250mg $2,360.00
AP10748 DBCO-PEG4-propionic EVCit-PAB DBCO-PEG4-propionic EVCit-PAB 1055.24 95% Pricing

AP10748

DBCO-PEG4-propionic EVCit-PAB
Unit Price(USD) Quantity
50mg $1,980.00
100mg $2,970.00
AP10749 DBCO-PEG4-Propionic-Val-Cit-PAB DBCO-PEG4-Propionic-Val-Cit-PAB 870.02 95% Pricing

AP10749

DBCO-PEG4-Propionic-Val-Cit-PAB
Unit Price(USD) Quantity
100mg $980.00
250mg $1,960.00
500mg $2,940.00
AP10752 EY-CBS Linker EY-CBS Linker 521.35 95% Pricing

AP10752

EY-CBS Linker
Unit Price(USD) Quantity
10mg $980.00
25mg $1,980.00
AP10016 Fmoc-Ala-Ala-Asn-PAB-PNB Fmoc-Ala-Ala-Asn-PAB-PNB 766.75 95% Pricing

AP10016

Fmoc-Ala-Ala-Asn-PAB-PNB
Unit Price(USD) Quantity
100mg $680.00
250mg $1,360.00
500mg $2,540.00
1g $3,800.00
AP10020 Fmoc-Ala-Ala-Asn(Trt)-OH Fmoc-Ala-Ala-Asn(Trt)-OH 738.83 Pricing

AP10020

Fmoc-Ala-Ala-Asn(Trt)-OH
Unit Price(USD) Quantity
100mg $300.00
250mg $600.00
500mg $1,000.00
1g $1,500.00
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