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Enzymatically cleavable peptide linkers have gained significant attention in ADC development. They offer superior plasma stability and target specific release mechanism.

Val-Cit and Phe-Lys are optimized peptide-based linkers that can be cleaved by lysosomal extracts and human cathepsin B. Val-Cit (vc) has been successfully implemented in ADCs with payloads such as MMAE/MMAF. Bifunctional p-aminobenzyl alcohol group (PAB) has been used to separate drugs from the site of enzymatic cleavage and minimize the influence of the drug structure and cytotoxic activity. Glutamic acid–valine–citrulline linkers have been reported to ensure in vivo stability and efficacy of antibody–drug conjugates.

Peptide Linkers
  • Ala-Ala-Asn-pab peptide Linkers
  • Val-ala linkers
  • Val-Cit-PAB Linkers
Catalog# Name Structure M.W. Purity Pricing
Val-Cit-PAB Linkers
AP10895BCN-PEG1-Val-Cit-OH565.67≥95% Buy
AP10896BCN-PEG1-Val-Cit-PABC-OH670.81≥95% Buy
AP10897BCN-PEG1-Val-Cit-PABC-PNP835.91≥95% Buy
AP11194Azido-PEG3-Val-Cit-PAB-OH608.7≥95% Buy
AP11196Azido-PEG3-Val-Cit-PAB-PNP773.8≥95% Buy
AP11195Azido-PEG4-Val-Cit-PAB-OH652.75≥95% Buy
AP11197BCN-PEG3-Val-Cit653.77≥95% Buy
AP11198BCN-PEG3-VC-PFP Ester819.82≥95% Buy
AP11192Mal-amido-PEG2-Val-Cit-PAB-OH689.77≥95% Buy
AP11193Mal-amido-PEG2-Val-Cit-PAB-PNP854.87≥95% Buy
AP11191Mal-PEG4-Val-Cit-PAB-PNP871.9≥95% Buy
AP11921MC (C5)-Val-Cit452.51≥95% Buy
AP11922SPDP-Val-Cit-PAB-OH576.73≥95% Buy
AP11923SPDP-Val-Cit-PAB-PNP741.84≥95% Buy
AP10899DBCO-PEG1-Val-Cit-PABC-OH694.83≥95% Buy
AP10891Azido-PEG1-Val-Cit-PABC-PNP685.7≥95% Buy
AP10892TCO-PEG1-Val-Cit-OH541.65≥95% Buy
AP10877Mc-Val-Ala-PAB-PNP651.67≥95% Buy
AP10894TCO-PEG1-Val-Cit-PABC-PNP811.89≥95% Buy
AP10005Boc-Val-Cit374.4≥95% Buy
AP10006Boc-Val-Cit-PAB479.59≥95% Buy
AP10021Boc-Val-Cit-PAB-PNP644.67≥95% Buy
AP10747DBCO-PEG4 acetic -EVCit-PAB1041.21≥95% Buy
AP10750DBCO-PEG4-acetic-Val-Cit-PAB855.99≥95% Buy
AP10748DBCO-PEG4-propionic EVCit-PAB1055.24≥95% Buy
AP10749DBCO-PEG4-Propionic-Val-Cit-PAB870.02≥95% Buy
AP10752EY-CBS Linker521.35≥95% Buy
AP10018Fmoc-Val-Cit-OH496.56≥95% Buy
AP10015Fmoc-Val-Cit-PAB601.7≥95% Buy
AP10017Fmoc-Val-Cit-PAB-PNP766.8≥95% Buy
AP10027FmocEVCit-PAB786.91≥95% Buy
AP10028FmocEVCit-PAB-PNP952.02≥95% Buy
AP10695Mal-PEG2-Val-Cit-PAB-OH618.7≥95% Buy
AP10696Mal-PEG4-Val-Cit-PAB-OH706.8≥95% Buy
AP10687MC-Val-Cit-PAB-OH572.7≥95% Buy
AP10694MC-Val-Cit-PAB-PNP737.8≥95% Buy
AP10889Azido-PEG1-Val-Cit-OH415.45≥95% Buy
AP10888Mal-PEG1-Val-Cit-PABC-PNP739.74≥95% Buy
AP10893TCO-PEG1-Val-Cit-PABC-OH646.79≥95% Buy
AP10880Val-Cit-OH274.32≥95% Buy
AP10881acid-propionylamino-Val-Cit-OH374.39≥95% Buy
AP10882MC(C2)-Val-Cit-PAB-OH530.58≥95% Buy
AP10883MC-Val-Cit-OH467.52≥95% Buy
AP10884Val-Cit-PAB-OH379.46≥95% Buy
AP10886Mal-PEG1-Val-Cit-OH469.5≥95% Buy
AP10887Mal-PEG1-Val-Cit-PABC-OH574.64≥95% Buy
AP10890Azido-PEG1-Val-Cit-PABC-OH520.59≥95% Buy
AP10898DBCO-PEG1-Val-Cit-OH589.69≥95% Buy
AP10900DBCO-PEG1-Val-Cit-PABC-PNP859.94≥95% Buy
AP11021exo-BCN-Val-Cit-PAB-PNP720.77≥95% Buy
Ala-Ala-Asn-pab peptide Linkers
AP10016Fmoc-Ala-Ala-Asn-PAB-PNP766.75≥95% Buy
AP10020Fmoc-Ala-Ala-Asn(Trt)-OH738.83 Buy
AP10013Fmoc-Ala-Ala-Asn(Trt)-PAB843.96≥95% Buy
AP10014Fmoc-Ala-Ala-Asn(Trt)-PAB-PNP1009.1≥95% Buy
AP10004MC-Ala-Ala-Asn(Trt)-OH709.79≥98% Buy
Val-ala linkers
AP10878Alloc-Val-Ala-PAB377.44≥95% Buy
AP10873Boc-Val-Ala-PAB393.48≥95% Buy
AP10874Val-Ala-PAB293.37≥95% Buy
AP10871Fmoc-Val-Ala-PAB-PNP680.71≥95% Buy
AP10876Mc-Val-Ala-PAB486.57≥95% Buy
AP10879Alloc-Val-Ala-PAB-PNP542.55≥95% Buy
AP10872Boc-Val-Ala-PAB-PNP558.59≥95% Buy
AP10875Fmoc-Val-ala-PAB515.61≥95% Buy