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Enzymatically cleavable peptide linkers have gained significant attention in ADC development. They offer superior plasma stability and target specific release mechanism.

Val-Cit and Phe-Lys are optimized peptide-based linkers that can be cleaved by lysosomal extracts and human cathepsin B. Val-Cit (vc) has been successfully implemented in ADCs with payloads such as MMAE/MMAF. Bifunctional p-aminobenzyl alcohol group (PAB) has been used to separate drugs from the site of enzymatic cleavage and minimize the influence of the drug structure and cytotoxic activity. Glutamic acid–valine–citrulline linkers have been reported to ensure in vivo stability and efficacy of antibody–drug conjugates.

Peptide Linkers
  • Val-Cit-PAB Linkers
  • Ala-Ala-Asn-pab peptide Linkers
  • Val-ala linkers
Catalog# Name Structure M.W. Purity Pricing
Val-Cit-PAB Linkers
AP10895BCN-PEG1-Val-Cit-OH565.67≥95% Pricing
AP10896BCN-PEG1-Val-Cit-PABC-OH670.81≥95% Pricing
AP10897BCN-PEG1-Val-Cit-PABC-PNP835.91≥95% Pricing
AP11194Azido-PEG3-Val-Cit-PAB-OH608.7≥95% Pricing
AP11196Azido-PEG3-Val-Cit-PAB-PNP773.8≥95% Pricing
AP11195Azido-PEG4-Val-Cit-PAB-OH652.75≥95% Pricing
AP11197BCN-PEG3-Val-Cit653.77≥95% Pricing
AP11198BCN-PEG3-VC-PFP Ester819.82≥95% Pricing
AP11192Mal-amido-PEG2-Val-Cit-PAB-OH689.77≥95% Pricing
AP11193Mal-amido-PEG2-Val-Cit-PAB-PNP854.87≥95% Pricing
AP11191Mal-PEG4-Val-Cit-PAB-PNP871.9≥95% Pricing
AP11921MC (C5)-Val-Cit452.51≥95% Pricing
AP11922SPDP-Val-Cit-PAB-OH576.73≥95% Pricing
AP11923SPDP-Val-Cit-PAB-PNP741.84≥95% Pricing
AP10899DBCO-PEG1-Val-Cit-PABC-OH694.83≥95% Pricing
AP10891Azido-PEG1-Val-Cit-PABC-PNP685.7≥95% Pricing
AP10892TCO-PEG1-Val-Cit-OH541.65≥95% Pricing
AP10877Mc-Val-Ala-PAB-PNP651.67≥95% Pricing
AP10894TCO-PEG1-Val-Cit-PABC-PNP811.89≥95% Pricing
AP10005Boc-Val-Cit374.4≥95% Pricing