acid-PEG2-NHS ester linker contains a carboxylic acid and an NHS ester. The PEG spacer increases the aqueous solubility of the resulting compound. The NHS ester can be used to conjugate with amine containing proteins, oligonucleotides, and other molecules. The terminal carboxylic acid readily reacts with primary and secondary amine under EDC, DCC, HATU or other amide coupling conditions to form a stable amide bond.
AxisPharm offers 4000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.