Acid-PEG4-NHS ester linker CAS:2639395-41-6 contains a carboxylic acid and an NHS ester. The PEG spacer increases the aqueous solubility of the resulting compound. The NHS ester can be used to conjugate with amine containing proteins, oligonucleotides, and other molecules.The terminal carboxylic acid readily reacts with primary and secondary amine under EDC, DCC, HATU or other amide coupling conditions to form a stable amide bond.
Acid-PEG4-NHS ester is a versatile reagent that can be used to introduce PEGylation to various biomolecules, such as antibodies, enzymes, and peptides, improving their solubility, stability, and pharmacokinetics. PEGylation can also reduce immunogenicity and prolong the half-life of biomolecules in the bloodstream, thereby improving their therapeutic efficacy.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.