Chloroacetamido-PEG4-t-Butyl Ester linker contains a chloroacetamide and a t-butyl ester. The chloride is a good leaving group and can undergo substitution reactions. The t-butyl group is an acid labile protecting group. Upon removal, the carboxylic acid can undergo amide coupling with amine bearing biomolecules. The hydrophilic PEG chain can increase the solubilty of compounds in aqueous media.
AxisPharm offers 4000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.