Bromoacetamido-PEG5-DOTA contains a bromoacetamide moiety and a t-butyl protecting group. DOTA is used as a chelating agent for cations. It has wide applications in tissue imaging, cancer diagnosis and treatment. The t-Butyl groups can be removed under acidic conditions to afford a free carboxylic acid. The bromoacetamide is widely used for thiol labelling and thiol capping reagent. It undergoes a fast nucleophilic substitution reaction with thiol. The PEG spacer can increase the solubility of compounds in aqueous media.
Axispharm offers 3000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.