Peptide Linkers

Enzymatically cleavable peptide linkers have gained significant attention in ADC development. They offer superior plasma stability and target specific release mechanism.

Val-Cit and Phe-Lys are optimized peptide-based linkers that can be cleaved by lysosomal extracts and human cathepsin B. Val-Cit (vc) has been successfully implemented in ADCs with payloads such as MMAE/MMAF. Bifunctional p-aminobenzyl alcohol group (PAB) has been used to separate drugs from the site of enzymatic cleavage and minimize the influence of the drug structure and cytotoxic activity. Glutamic acid–valine–citrulline linkers have been reported to ensure in vivo stability and efficacy of antibody–drug conjugates.

AxisPharm has successfully developed technology to produced a series of peptide linkers, such as Fmoc-Val-Cit-PAB, Fmoc-Phe-Lys(Trt)-PAB, Fmoc-Ala-Ala-Asn(Trt)-PAB-PNP, Fmoc-Ala-Ala-Asn-PAB-PNP, and Glutamic acid–valine–citrulline linkers, etc. from gram to kilogram scale in high quality. Our customized ADC conjugation service helps our clients design and select the most suitable linker based on efficacy and toxicity requirement of individual ADCs, all with the best quality and in an cost-effective way.

For inquiries, please call us at: 858-677-9432. or email us at: info@axispharm.com

Catalog No. Name Structure M.W. Purity Pricing
AP10878 Alloc-Val-Ala-PAB Alloc-Val-Ala-PAB 377.44 95% Pricing

AP10878

Alloc-Val-Ala-PAB
Unit Price(USD) Quantity
500 mg $654.00
1000 mg $980.00
AP10879 Alloc-Val-Ala-PAB-PNP Alloc-Val-Ala-PAB-PNP 542.55 95% Pricing

AP10879

Alloc-Val-Ala-PAB-PNP
Unit Price(USD) Quantity
500 mg $534.00
1000 mg $800.00
AP10889 Azido-PEG1-Val-Cit-OH Azido-PEG1-Val-Cit-OH 415.45 95% Pricing

AP10889

Azido-PEG1-Val-Cit-OH
Unit Price(USD) Quantity
100 mg $425.00
250 mg $850.00
500 mg $1,275.00
AP10891 Azido-PEG1-Val-Cit-PABC-PNP Azido-PEG1-Val-Cit-PABC-PNP 685.7 95% Pricing

AP10891

Azido-PEG1-Val-Cit-PABC-PNP
Unit Price(USD) Quantity
100 mg $425.00
250 mg $850.00
500 mg $1,275.00
AP10895 BCN-PEG1-Val-Cit-OH BCN-PEG1-Val-Cit-OH 565.67 95% Pricing

AP10895

BCN-PEG1-Val-Cit-OH
Unit Price(USD) Quantity
100 mg $425.00
250 mg $850.00
500 mg $1,275.00
AP10896 BCN-PEG1-Val-Cit-PABC-OH BCN-PEG1-Val-Cit-PABC-OH 670.81 95% Pricing

AP10896

BCN-PEG1-Val-Cit-PABC-OH
Unit Price(USD) Quantity
100 mg $425.00
250 mg $850.00
500 mg $1,275.00
AP10897 BCN-PEG1-Val-Cit-PABC-PNP BCN-PEG1-Val-Cit-PABC-PNP 835.91 95% Pricing

AP10897

BCN-PEG1-Val-Cit-PABC-PNP
Unit Price(USD) Quantity
100 mg $425.00
250 mg $850.00
500 mg $1,275.00
AP10873 Boc-Val-Ala-PAB Boc-Val-Ala-PAB 393.48 95% Pricing

AP10873

Boc-Val-Ala-PAB
Unit Price(USD) Quantity
250 mg $400.00
500 mg $600.00
1000 mg $980.00
AP10872 Boc-Val-Ala-PAB-PNP Boc-Val-Ala-PAB-PNP 558.59 95% Pricing

AP10872

Boc-Val-Ala-PAB-PNP
Unit Price(USD) Quantity
250 mg $400.00
500 mg $750.00
1000 mg $1,280.00
AP10005 Boc-Val-Cit Boc-Val-Cit 374.4 95% Pricing

AP10005

Boc-Val-Cit
Unit Price(USD) Quantity
100mg $70.00
250mg $120.00
1g $240.00
5g $710.00
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