Peptide Linkers

Enzymatically cleavable peptide linkers have gained significant attention in ADC development. They offer superior plasma stability and target specific release mechanism.

Val-Cit and Phe-Lys are optimized peptide-based linkers that can be cleaved by lysosomal extracts and human cathepsin B. Val-Cit (vc) has been successfully implemented in ADCs with payloads such as MMAE/MMAF. Bifunctional p-aminobenzyl alcohol group (PAB) has been used to separate drugs from the site of enzymatic cleavage and minimize the influence of the drug structure and cytotoxic activity. Glutamic acid–valine–citrulline linkers have been reported to ensure in vivo stability and efficacy of antibody–drug conjugates.

Catalog No. Name Structure M.W. Purity Pricing
AP10895 BCN-PEG1-Val-Cit-OH BCN-PEG1-Val-Cit-OH 565.67 95% Pricing

AP10895

BCN-PEG1-Val-Cit-OH
Unit Price(USD) Quantity
100 mg $425.00
250 mg $850.00
500 mg $1,275.00
AP10896 BCN-PEG1-Val-Cit-PABC-OH BCN-PEG1-Val-Cit-PABC-OH 670.81 95% Pricing

AP10896

BCN-PEG1-Val-Cit-PABC-OH
Unit Price(USD) Quantity
100 mg $425.00
250 mg $850.00
500 mg $1,275.00
AP10897 BCN-PEG1-Val-Cit-PABC-PNP BCN-PEG1-Val-Cit-PABC-PNP 835.91 95% Pricing

AP10897

BCN-PEG1-Val-Cit-PABC-PNP
Unit Price(USD) Quantity
100 mg $425.00
250 mg $850.00
500 mg $1,275.00
Val-Cit-PAB Linkers
AP10899 DBCO-PEG1-Val-Cit-PABC-OH DBCO-PEG1-Val-Cit-PABC-OH 694.83 95% Pricing

AP10899

DBCO-PEG1-Val-Cit-PABC-OH
Unit Price(USD) Quantity
100 mg $425.00
250 mg $850.00
500 mg $1,275.00
Val-ala linkers
AP10878 Alloc-Val-Ala-PAB Alloc-Val-Ala-PAB 377.44 95% Pricing

AP10878

Alloc-Val-Ala-PAB
Unit Price(USD) Quantity
500 mg $654.00
1000 mg $980.00
AP10891 Azido-PEG1-Val-Cit-PABC-PNP Azido-PEG1-Val-Cit-PABC-PNP 685.7 95% Pricing

AP10891

Azido-PEG1-Val-Cit-PABC-PNP
Unit Price(USD) Quantity
100 mg $425.00
250 mg $850.00
500 mg $1,275.00
AP10892 TCO-PEG1-Val-Cit-OH TCO-PEG1-Val-Cit-OH 541.65 95% Pricing

AP10892

TCO-PEG1-Val-Cit-OH
Unit Price(USD) Quantity
100 mg $425.00
250 mg $850.00
500 mg $1,275.00
AP10873 Boc-Val-Ala-PAB Boc-Val-Ala-PAB 393.48 95% Pricing

AP10873

Boc-Val-Ala-PAB
Unit Price(USD) Quantity
250 mg $400.00
500 mg $600.00
1000 mg $980.00
AP10877 Mc-Val-Ala-PAB-PNP Mc-Val-Ala-PAB-PNP 651.67 95% Pricing

AP10877

Mc-Val-Ala-PAB-PNP
Unit Price(USD) Quantity
100 mg $374.00
250 mg $747.00
500 mg $1,120.00
1000 mg $1,680.00
AP10894 TCO-PEG1-Val-Cit-PABC-PNP TCO-PEG1-Val-Cit-PABC-PNP 811.89 95% Pricing

AP10894

TCO-PEG1-Val-Cit-PABC-PNP
Unit Price(USD) Quantity
100 mg $425.00
250 mg $850.00
500 mg $1,275.00
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