TCO Linkers

TCO Linkers are bioorthogonal agents for tetrazine. The cycloaddition reaction between tetrazine and trans-cyclooctene (TCO) is rapidly growing in use for bioconjugation, molecular imaging and cell-based diagnostics.

The chemoselective TCO–Tz ligation pair possess ultrafast kinetics unmatched by any other bioorthogonal ligation pair.

Hydrophobic TCOs can be masked to lose activity by hydrophobic interactions with mAb. However, pegylating TCOs with polyethylene glycol (PEG) spacers help minimize the interaction and improve the activity. In addition, PEG spacers help reduce aggregation of mAb conjugates and provide increased water solubility, reduced immunogenicity, improved pharmacokinetics and pharmacodynamics properties.

AxisPharm has large production capacity for high quality TCO PEG linkers with amine, aminooxy, NHS ester and acid functionality. We also provide custom synthesis of TCO PEG modified folate, biotin and fluorescent dye for biological applications.

Catalog No. Name Structure M.W. Purity Pricing
AP10141 aminooxy-PEG2-TCO aminooxy-PEG2-TCO 387.48 95% Pricing

AP10141

aminooxy-PEG2-TCO
Unit Price(USD) Quantity
100mg $750.00
250mg $1,500.00
500mg $2,250.00
1g $3,380.00
AP10840 Bis-TCO-PEG2 Bis-TCO-PEG2 452.58 95% Pricing

AP10840

Bis-TCO-PEG2
Unit Price(USD) Quantity
100 mg $490.00
250 mg $980.00
500 mg $1,470.00
1000 mg $2,205.00
AP10841 Bis(TCO)-PEG5 Bis(TCO)-PEG5 584.74 95% Pricing

AP10841

Bis(TCO)-PEG5
Unit Price(USD) Quantity
100 mg $490.00
250 mg $980.00
500 mg $1,470.00
1000 mg $2,205.00
AP10142 Bocaminooxy-PEG2-TCO Bocaminooxy-PEG2-TCO 487.59 95% Pricing

AP10142

Bocaminooxy-PEG2-TCO
Unit Price(USD) Quantity
100mg $700.00
250mg $1,400.00
500mg $2,100.00
1g $3,150.00
AP10599 HyNic-PEG2-TCO HyNic-PEG2-TCO 475.59 95% Pricing

AP10599

HyNic-PEG2-TCO
Unit Price(USD) Quantity
25 mg $350.00
50 mg $560.00
100 mg $880.00
AP10608 HyNic-PEG3-TCO HyNic-PEG3-TCO 535.64 95% Pricing

AP10608

HyNic-PEG3-TCO
Unit Price(USD) Quantity
25 mg $350.00
50 mg $560.00
100 mg $880.00
AP10039 TCO PEG3 CH2CO2H TCO PEG3 CH2CO2H 359.41 98% Pricing

AP10039

TCO PEG3 CH2CO2H
Unit Price(USD) Quantity
100mg $440.00
250mg $870.00
500mg $1,650.00
1g $2,480.00
AP10040 TCO PEG3 CH2CONHS TCO PEG3 CH2CONHS 456.49 98% Pricing

AP10040

TCO PEG3 CH2CONHS
Unit Price(USD) Quantity
100mg $440.00
250mg $870.00
500mg $1,650.00
1g $2,480.00
AP10600 TCO-Acetic acid TCO-Acetic acid 184.24 95% Pricing

AP10600

TCO-Acetic acid
Unit Price(USD) Quantity
100 mg $680.00
250 mg $1,360.00
500 mg $2,280.00
AP10102 TCO-C3 Silane TCO-C3 Silane 373.56 95% Pricing

AP10102

TCO-C3 Silane
Unit Price(USD) Quantity
50mg $320.00
100mg $540.00
250mg $1,080.00
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