TCO PEG NHS

TCO PEG NHS linkers have TCO moiety on one end that can undergo biorthogonal reaction with tetrazine modified biomolecules. At meantime, the NHS ester functional group on the other end provides opportunity for conjugation with molecules bearing amine groups in a fast and efficient fashion.

Although both reactions are fast and high yielding, they don’t interfere with each other. Therefore, TCO PEG NHS spacer can be used in a consecutive or a simultaneous way for bioconjugations.