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TCO Linkers are bioorthogonal agents for tetrazine. The cycloaddition reaction between tetrazine and trans-cyclooctene (TCO) is rapidly growing in use for bioconjugation, molecular imaging and cell-based diagnostics.

The chemoselective TCO–Tz ligation pair possess ultrafast kinetics unmatched by any other bioorthogonal ligation pair.

Hydrophobic TCOs can be masked to lose activity by hydrophobic interactions with mAb. However, pegylating TCOs with polyethylene glycol (PEG) spacers help minimize the interaction and improve the activity. In addition, PEG spacers help reduce aggregation of mAb conjugates and provide increased water solubility, reduced immunogenicity, improved pharmacokinetics and pharmacodynamics properties.

AxisPharm has large production capacity for high quality TCO PEG linkers with amine, aminooxy, NHS ester and acid functionality. We also provide custom synthesis of TCO PEG modified folate, biotin and fluorescent dye for biological applications.

Catalog# Name Structure M.W. Purity Pricing
TCO PEG NHS
AP10040TCO PEG3 CH2CONHS456.49≥98% Pricing
AP10003TCO-NHS267.3≥95% Pricing
AP10601TCO-NHS Acetate281.31≥95% Pricing
AP10815TCO-PEG1-propionic NHS ester382.41≥95% Pricing
AP10846TCO-carbonylamino-benzyl NHS ester386.4≥95% Pricing
AP10816TCO-PEG2-propionic NHS ester426.47≥95% Pricing
AP10817TCO-PEG3-propionic NHS ester470.52≥95% Pricing
AP10847TCO-carbonylamino-benzamido-PEG1 NHS ester501.53≥95% Pricing
AP10818TCO-PEG4-propionic NHS ester514.57≥95% Pricing
AP10848TCO-carbonylamino-benzamido-PEG2 NHS ester545.58≥95% Pricing
AP10819TCO-PEG5-propionic NHS ester558.63≥95% Pricing
AP10849TCO-carbonylamino-benzamido-PEG3 NHS ester589.63≥95% Pricing
AP10820TCO-PEG6-propionic NHS ester602.68≥95% Pricing
AP10850TCO-carbonylamino-benzamido-PEG4 NHS ester633.69≥95% Pricing
AP10821TCO-PEG7-propionic NHS ester646.73≥95% Pricing
AP11858TCO-PEG8-NHS ester690.78≥95% Pricing
AP11859TCO-PEG12-NHS ester867≥95% Pricing
AP11863TCO-PNB Ester291.3≥95% Pricing
Aminooxy-PEG-TCO
AP10141aminooxy-PEG2-TCO HCl Salt in solution373.45≥95% Pricing
AP10142Bocaminooxy-PEG2-TCO473.57≥95% Pricing