TCO Linkers

TCO Linkers are bioorthogonal agents for tetrazine. The cycloaddition reaction between tetrazine and trans-cyclooctene (TCO) is rapidly growing in use for bioconjugation, molecular imaging and cell-based diagnostics.

The chemoselective TCO–Tz ligation pair possess ultrafast kinetics unmatched by any other bioorthogonal ligation pair.

Hydrophobic TCOs can be masked to lose activity by hydrophobic interactions with mAb. However, pegylating TCOs with polyethylene glycol (PEG) spacers help minimize the interaction and improve the activity. In addition, PEG spacers help reduce aggregation of mAb conjugates and provide increased water solubility, reduced immunogenicity, improved pharmacokinetics and pharmacodynamics properties.

AxisPharm has large production capacity for high quality TCO PEG linkers with amine, aminooxy, NHS ester and acid functionality. We also provide custom synthesis of TCO PEG modified folate, biotin and fluorescent dye for biological applications.

Catalog No. Name Structure M.W. Purity Pricing
AP10598 TCO-PEG1-Br TCO-PEG1-Br 233.15 95% Pricing

AP10598

TCO-PEG1-Br
Unit Price(USD) Quantity
250mg $1,780.00
500mg $2,680.00
1g $4,020.00
100 mg $895.00
HyNic-PEG-TCO
AP10599 HyNic-PEG2-TCO HyNic-PEG2-TCO 475.59 95% Pricing

AP10599

HyNic-PEG2-TCO
Unit Price(USD) Quantity
25 mg $350.00
50 mg $560.00
100 mg $880.00
AP10608 HyNic-PEG3-TCO HyNic-PEG3-TCO 535.64 95% Pricing

AP10608

HyNic-PEG3-TCO
Unit Price(USD) Quantity
25 mg $350.00
50 mg $560.00
100 mg $880.00
AP10892 TCO-PEG1-Val-Cit-OH TCO-PEG1-Val-Cit-OH 541.65 95% Pricing

AP10892

TCO-PEG1-Val-Cit-OH
Unit Price(USD) Quantity
100 mg $425.00
250 mg $850.00
500 mg $1,275.00
AP10894 TCO-PEG1-Val-Cit-PABC-PNP TCO-PEG1-Val-Cit-PABC-PNP 811.89 95% Pricing

AP10894

TCO-PEG1-Val-Cit-PABC-PNP
Unit Price(USD) Quantity
100 mg $425.00
250 mg $850.00
500 mg $1,275.00
AP10840 Bis-TCO-PEG2 Bis-TCO-PEG2 452.58 95% Pricing

AP10840

Bis-TCO-PEG2
Unit Price(USD) Quantity
100 mg $490.00
250 mg $980.00
500 mg $1,470.00
1000 mg $2,205.00
AP10841 Bis(TCO)-PEG5 Bis(TCO)-PEG5 584.74 95% Pricing

AP10841

Bis(TCO)-PEG5
Unit Price(USD) Quantity
100 mg $490.00
250 mg $980.00
500 mg $1,470.00
1000 mg $2,205.00
AP10893 TCO-PEG1-Val-Cit-PABC-OH TCO-PEG1-Val-Cit-PABC-OH 646.79 95% Pricing

AP10893

TCO-PEG1-Val-Cit-PABC-OH
Unit Price(USD) Quantity
100 mg $425.00
250 mg $850.00
500 mg $1,275.00
AP10830 TCO-PEG2-amine TCO-PEG2-amine 300.4 95% Pricing

AP10830

TCO-PEG2-amine
Unit Price(USD) Quantity
10 mg $220.00
25 mg $440.00
50 mg $660.00
AP10851 TCO-carbonylamino-benzamido-PEG1 acid TCO-carbonylamino-benzamido-PEG1 acid 404.46 95% Pricing

AP10851

TCO-carbonylamino-benzamido-PEG1 acid
Unit Price(USD) Quantity
100 mg $460.00
250 mg $920.00
500 mg $1,360.00
Menu