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VH-298 is an E3 ubiquitin ligase, a potent and selective VHL inhibitor (Kd value of 80-90 nM), VH298 acts on the downstream of PHD enzyme, it can effectively destroy the interaction between VHL and hypoxia-inducible factor HIF-α Interaction, upregulates the mRNA and protein levels of HIF target genes, resulting in a transcriptional signature similar to hypoxia.


Cat# Name Structure M.W. Purity Pricing
AP14678VH-298523.70≥95% Pricing

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