Idasanutlin (RG-7388) is a potent p53-MDM2 inhibitor with IC50 of 6 nM, showing improved in vitro binding and cellular potency/selectivity. IC50 = 30 nM in cancer cell proliferation assay. Induces p53 stabilization, cell cycle arrest and apoptosis in cancer cells expressing wild-type p53. Shows inhibition of tumor growth in the SJSA1 tumor xenograft model. Also inhibits MDR-1 at high concentrations.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.