VH-298 is an E3 ubiquitin ligase, a potent and selective VHL inhibitor (Kd value of 80-90 nM), VH298 acts on the downstream of PHD enzyme, it can effectively destroy the interaction between VHL and hypoxia-inducible factor HIF-α Interaction, the reason why VH298 can stimulate erythropoietin production in RCC4 cells is because H298 can induce HIF transcriptional activity and increase the accumulation of HIF-α in HeLa cells.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.