GSK-5959 is a potent, selective and cell-permeable BRPF1 bromodomain inhibitor with IC50 ~80 nM. More than 100-fold selectivity for BRPF1 (IC50 = 80 nM) over other 35 bromodomains including BRPF2/3 and BET family bromodomains. Inhibits the interaction of BRPF1 with histone H3.3, which is involved in epigenetic regulation of gene expression and has been implicated in human cancer.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.