(S,R. S)-AHPC-PEG4-amine hydrochloride salt is a protein degrader builiding block used in the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. It contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with terminal amine. The amine bearing building block can be used parrelly through a formation of amide bond with acid and active acid ester tagged biomolecules to quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. PEG spacer increase aqueous solubility.
Axispharm offers 3000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.