(S,R. S)-AHPC-PEG4-Azide is a protein degrader builiding block used in the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. It contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. The azide bearing building block can be used parrelly with alkyne-tagged biomolecules to quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. PEG spacer increase aqueous solubility.
Axispharm offers 3000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.