HyNic PEG
HyNic PEG Linker
The HyNic PEG linker combines a 6-HydrazinoNicotinamide (HyNic) on one end, a PEG spacer in the middle, and a functional group on the other. It specifically reacts with 4-FormylBenzamide-modified biomolecules to form stable hydrazone bonds. The PEG spacer boosts water solubility, making the bioconjugates more effective in biological applications.
Key Features
- HyNic Group: The HyNic end reacts with 4-FormylBenzamide, forming a stable bond under mild conditions.
- PEG Spacer: The PEG chain increases water solubility and provides flexibility. It also reduces aggregation, improving the performance of the conjugates.
- Dual Functional Ends: Offers a functional group at the other end for further modifications.
Applications
- Bioconjugation: Links proteins, peptides, and other molecules to drugs, labels, or probes.
- Antibody-Drug Conjugates (ADCs): Connects antibodies to drug payloads for targeted therapies.
- Diagnostics and Imaging: Attaches tracers to targeting molecules for probes and imaging agents.
- Surface Modification: Adds biomolecules to surfaces for better biocompatibility or functionalization.
Advantages
- Enhanced Solubility: The PEG spacer significantly improves water solubility, making it suitable for biological environments.
- Specific Conjugation: Forms stable hydrazone bonds with 4-FormylBenzamide, ensuring precise and controlled linking.
- Adjustable Linker Lengths: Available in different PEG sizes to customize the distance between linked molecules.
Product Options
- Custom Modifications: Tailored options for specific applications or additional functional groups.
The HyNic PEG linker provides a reliable way to achieve precise, stable, and soluble bioconjugation, ideal for research, diagnostics, and therapy.