Boc-HyNic-PEG-Azide is a chemical compound that belongs to the class of bifunctional molecules used in drug research and development. This molecule is composed of three functional groups – the Boc (tert-butyloxycarbonyl) protecting group, the HyNic (6-hydroxy-nicotinic acid) coupling agent, and the PEG (polyethylene glycol) linker, with an azide group at the end.
Boc-HyNic-PEG-Azide is a valuable tool for drug discovery because it enables the conjugation of small molecules, peptides, and proteins to a variety of surfaces, including nanoparticles and polymers. The PEG linker improves the solubility and stability of the conjugated compounds, while the HyNic coupling agent facilitates the covalent attachment of the azide group to a range of biomolecules.
This versatile molecule has gained widespread use in the development of targeted drug delivery systems, such as antibody-drug conjugates (ADCs) and peptide-drug conjugates (PDCs), which have shown great promise in treating cancer and other diseases. Boc-HyNic-PEG-Azide has also been used in the development of imaging agents and diagnostic tools, as well as in the synthesis of bioconjugates for biological research.