4-Aminobutyl-DOTA provides an amine-functionalized macrocyclic chelator for radiolabeling, bioconjugation, and molecular imaging research and specifically combines the metal-chelating DOTA framework with a four-carbon aminobutyl linker containing a primary amine. This structure specifically supports metal ion coordination and covalent attachment to suitable biomolecules, polymers, and functionalized surfaces.
Key Features and Benefits
- DOTA Chelating Framework: Contains a macrocyclic tetraazacyclododecane-based chelator specifically designed to coordinate suitable metal ions through nitrogen and oxygen donor atoms.
- Primary Amine Functionality: Provides a terminal amino group specifically for covalent conjugation with activated carboxyl groups and other amine-reactive functionalities.
- Four-Carbon Linker: Incorporates an aminobutyl spacer that separates the chelating framework from the conjugation site.
- Metal Coordination Capability: Supports complexation studies with compatible radiometals and nonradioactive metal ions under appropriate reaction conditions.
- Bioconjugation Compatibility: Enables attachment to peptides, proteins, polymers, and other molecules bearing suitable reactive functional groups.
- EDC/NHS Coupling Compatibility: Supports amide bond formation between the terminal primary amine and activated carboxyl-containing molecules.
- Radiolabeling Research Utility: Provides a functional chelator platform for investigating radiometal incorporation, labeling efficiency, and complex stability.
- Versatile Chemical Modification: Supports development of functionalized chelator derivatives for molecular imaging, analytical chemistry, and targeted delivery research.
Applications
- Radiopharmaceutical Research: Supports development of radiometal-chelator conjugates for investigational diagnostic and therapeutic applications.
- Molecular Imaging: Useful for preparing metal-chelate constructs for PET, SPECT, and other imaging research involving compatible metal ions.
- Peptide Conjugation: Enables attachment of DOTA functionality to carboxyl-containing peptides through suitable amide coupling reactions.
- Protein Bioconjugation: Supports preparation of chelator-functionalized proteins using compatible amine-reactive coupling strategies.
- Radiometal Labeling Studies: Useful for investigating radiolabeling conditions, metal incorporation, and complex formation.
- Targeted Imaging Agent Development: Supports conjugation of metal-chelating groups to targeting ligands for molecular recognition studies.
- Polymer Functionalization: Enables incorporation of DOTA chelators into appropriately functionalized polymer systems and biomaterials.
- Coordination Chemistry Research: Supports investigation of metal-binding behavior, complex stability, and coordination properties.
- Analytical Method Development: Useful for evaluating chelation efficiency, conjugation chemistry, and metal-complex characterization.
Storage and Handling
- Storage: Store in a tightly sealed container under dry conditions, following the product-specific storage specifications. Protect from moisture, excessive heat, and incompatible reagents.
- Handling: Use appropriate laboratory precautions and avoid contamination with trace metals. For bioconjugation, select suitable coupling reagents and reaction conditions that preserve the DOTA chelating framework. Use metal-free reagents and containers when required for sensitive chelation studies.
4-Aminobutyl-DOTA combines a macrocyclic DOTA chelator with a terminal primary amine for versatile chemical modification and specifically supports radiometal labeling, peptide and protein conjugation, molecular imaging, and advanced coordination chemistry research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
