p-NH2-Bn-NOTA provides an amine-functionalized macrocyclic chelator for radiometal labeling, bioconjugation, and molecular imaging research and specifically combines the NOTA (1,4,7-triazacyclononane-1,4,7-triacetic acid) chelating framework with a para-aminobenzyl functional group. This bifunctional structure specifically supports metal ion coordination and covalent attachment to peptides, proteins, and other suitable biomolecules.
Key Features and Benefits
- NOTA Chelating Framework: Features a nine-membered triazamacrocyclic ring with three pendant carboxylate groups for coordination of compatible metal ions.
- Para-Aminobenzyl Functionality: Provides an aromatic primary amine for chemical modification and conjugation with suitable reactive groups.
- Bifunctional Chelator Design: Combines metal coordination and bioconjugation capabilities within a single molecule for targeted imaging research.
- Radiometal Coordination: Supports complexation with compatible radiometals, including gallium-68 and copper-64, under optimized labeling conditions.
- Stable Metal Complex Formation: The NOTA macrocycle supports formation of thermodynamically stable metal complexes with suitable metal ions.
- Aromatic Linker Structure: The benzyl group separates the chelating framework from the reactive amine, supporting further chemical modification.
- Versatile Conjugation Chemistry: The aromatic amino group enables derivatization specifically through suitable amine-reactive coupling and functionalization strategies.
- Radiopharmaceutical Research Utility: Supports development and evaluation of radiometal-labeled molecular probes for diagnostic imaging research.
Applications
- PET Imaging Research: Supports development of investigational radiometal-labeled probes specifically for positron emission tomography using compatible radionuclides.
- Gallium-68 Radiolabeling: Useful for investigating NOTA-based gallium-68 complexation, radiochemical yield, and labeling stability.
- Copper-64 Radiolabeling: Supports evaluation of copper-64 coordination and radiolabeled molecular imaging constructs.
- Peptide Bioconjugation: Enables preparation of NOTA-functionalized peptides through suitable aromatic amine derivatization and coupling reactions.
- Protein Modification: Supports development of chelator-functionalized proteins using compatible bioconjugation strategies.
- Targeted Molecular Imaging: Useful for attaching NOTA chelators to targeting ligands specifically for receptor-binding and imaging studies.
- Radiopharmaceutical Development: Supports research into radiometal-chelator conjugates specifically for diagnostic applications.
- Coordination Chemistry Research: Enables investigation of metal-binding properties, complex stability, and radiometal coordination behavior.
- Analytical Method Development: Supports evaluation of radiolabeling efficiency, conjugation chemistry, and metal-complex characterization.
Storage and Handling
- Storage: Store at −20°C in a dry, tightly sealed container unless otherwise specified. Protect from moisture, light, and excessive heat.
- Handling: Handle using appropriate laboratory precautions and minimize trace-metal contamination. Use metal-free reagents and suitable reaction vessels for sensitive radiolabeling studies. Select coupling conditions compatible with the aromatic primary amine and NOTA chelating framework.
p-NH2-Bn-NOTA combines a NOTA macrocyclic chelator with a reactive para-aminobenzyl group for versatile chemical modification and specificallysupports PET imaging research, radiometal labeling, peptide and protein conjugation, and advanced coordination chemistry studies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
