NO2A-Butyne provides an alkyne-functionalized macrocyclic chelator for click chemistry, metal coordination, and molecular imaging research and specifically combines a 1,4,7-triazacyclononane-based NO2A framework with two acetic acid groups and a butyne-derived functionality. This bifunctional structure specifically supports conjugation with azide-containing molecules and preparation of metal-chelate constructs for radiopharmaceutical research.
Key Features and Benefits
- NO2A Macrocyclic Framework: Features a triazacyclononane-based chelator with two pendant acetate groups specifically for coordination of compatible metal ions.
- Alkyne Functionality: Provides an alkyne group for covalent attachment to azide-functionalized molecules specifically through suitable click chemistry reactions.
- Click Chemistry Compatibility: Supports copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) specifically for preparing triazole-linked molecular conjugates.
- Bifunctional Chelator Design: Combines metal coordination and chemical conjugation capabilities within a single functionalized macrocyclic compound.
- Butyne-Derived Functional Group: Incorporates a short alkyne-containing structural component specifically for introducing NO2A functionality into suitable molecular systems.
- Radiometal Coordination: Supports investigation of complexation with compatible radiometals, including copper-64, under optimized reaction conditions.
- Stable Triazole Linkage: Enables formation of covalent triazole bonds through reactions with suitable organic azides.
- Versatile Biomolecular Modification: Supports attachment of NO2A functionality to azide-modified peptides, proteins, polymers, and targeting ligands.
Applications
- Click Chemistry Bioconjugation: Supports CuAAC-mediated attachment of NO2A chelators to azide-containing biomolecules and synthetic compounds.
- Radiopharmaceutical Research: Enables preparation of functionalized macrocyclic chelators for investigational radiometal labeling applications.
- Copper-64 Radiolabeling: Useful for investigating copper-64 coordination, radiochemical yield, and stability of NO2A-based complexes.
- Peptide Functionalization: Supports preparation of NO2A-modified peptides through conjugation with azide-containing peptide sequences.
- Protein Bioconjugation: Enables introduction of macrocyclic chelating groups into proteins containing appropriately incorporated azide functionalities.
- PET Imaging Research: Supports development of investigational radiometal-labeled probes for positron emission tomography.
- Polymer Modification: Useful for incorporating NO2A chelators into azide-functionalized polymers, nanoparticles, and biomaterials.
- Targeted Molecular Imaging: Supports preparation of chelator-functionalized targeting ligands for receptor-binding and imaging studies.
- Coordination Chemistry Research: Enables investigation of metal-binding properties, complex formation, and physicochemical characteristics of NO2A derivatives.
Storage and Handling
- Storage: Store at −20°C in a dry, tightly sealed container unless otherwise specified. Protect from moisture, excessive heat, and prolonged light exposure.
- Handling: Handle using appropriate laboratory precautions and minimize trace-metal contamination. For CuAAC reactions, use suitable copper catalysts, ligands, and azide-functionalized reaction partners. Remove residual copper when necessary before subsequent radiometal labeling or biological studies.
NO2A-Butyne combines a macrocyclic NO2A chelator with an alkyne functionality for versatile click chemistry conjugation and specifically supports radiometal coordination, peptide and protein modification, molecular imaging, and development of functionalized radiopharmaceutical research compounds.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
