DOTA PEG linkers are an important class of molecules widely used in pharmaceutical research and development. These linkers are composed of a DOTA chelator and a polyethylene glycol (PEG) chain. The DOTA moiety is used to bind to metal ions such as copper, gallium or lutetium, while the PEG chain provides stability and solubility to the resulting conjugate.
The use of it is particularly relevant in the development of targeted molecular imaging and therapy. By conjugating the DOTA PEG linker to a targeting molecule, such as an antibody or a small molecule ligand, it is possible to selectively deliver a therapeutic agent to specific cells or tissues in the body. Additionally, the DOTA chelator can be used to label the resulting conjugate with a radioactive isotope, allowing for non-invasive imaging of the target site.
DOTA PEG linkers have also been employed in the development of novel therapeutics for the treatment of cancer, neurological disorders and inflammatory diseases. These linkers can improve the pharmacokinetic properties of the resulting drug conjugate, such as increasing its half-life and reducing its immunogenicity.
|AP12200||DOTA-PEG5-amine HCl salt||666.77||≥95%||Pricing|
|Other DOTA PEG|