Diazirine Linkers

Diazirine linkers, such as trifluoromethyl phenyl DAs and alkyl DAs, generate reactive carbene species via loss of N2 upon photoirradiation at 350 nm. This active carbene easily inserts into neighboring C–H or heteroatom–H bonds and forms a covalent adduct. Additionally, the generated carbene has a quick half-life in the nanosecond range.