3-[3-(but-3-yn-1-yl)-3H-diazirin-3-yl]propanoic acid

3-[3-(but-3-yn-1-yl)-3H-diazirin-3-yl]propanoic acid CAS:1450754-37-6 is a chemical compound that is commonly used in chemical biology and biochemistry. It is a diazirine-containing molecule, which makes it useful as a photo-crosslinking agent for studying protein-protein interactions and protein-ligand interactions.

3-[3-(but-3-yn-1-yl)-3H-diazirin-3-yl]propanoic acid contains a reactive diazirine group, which can be activated by UV light to form a highly reactive carbene intermediate. This carbene intermediate can react with nearby amino acid residues in proteins to form a covalent bond, allowing for the identification of protein-protein or protein-ligand interactions.

3-[3-(but-3-yn-1-yl)-3H-diazirin-3-yl]propanoic acid is frequently used in the development of photo-crosslinking probes and assays for studying protein-protein interactions, as well as for the identification of ligand-binding sites in proteins. It can also be used to modify peptides and small molecules to create diazirine-containing derivatives for use in chemical biology applications.

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