![3-[3-(but-3-yn-1-yl)-3H-diazirin-3-yl]propanoic acid](https://e1752fbe.rocketcdn.me/wp-content/uploads/AP11011-CAS-1450754-37-6-1-e1699585451616.png)
3-[3-(But-3-yn-1-yl)-3H-diazirin-3-yl]propanoic acid (CAS: 1450754-37-6)
Description:
This compound is a versatile chemical probe used in biochemical research, featuring three functional groups:
- Diazirine Group: Photoactivates under UV light to form a highly reactive carbene, which binds covalently to nearby biomolecules.
- Alkyne Group: Enables bioorthogonal conjugation via click chemistry, allowing attachment of tags or labels.
- Carboxylic Acid Group: Conjugates with amine-containing molecules, such as proteins, through standard amide bond formation.
Applications:
- Photoaffinity Labeling: Identifies protein-ligand interactions by forming bonds under UV activation.
- Chemical Probe Development: Attaches selectively to biomolecules for detection or isolation.
- Crosslinking Studies: Stabilizes transient protein-protein or protein-nucleic acid interactions for analysis.
Storage:
Store in the dark under inert gas, below -20°C, to preserve stability and reactivity.
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