Val-cit-pab linkers have been widely used in Antibody drug conjugation development. They have superior plasma stability to other peptide linkers. Val-cit-pab linkers are cleavable by cathepsin. The cleavage of val-cit-PAB linked amide releases the free parent drug through a 1,6-elimination of carbon dioxide.
Mc-val-cit-pab linker is a peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs) for various ADC payloads.