PLGA Acid Capped (PLGA-COOH, 75:25) MW 80K is ultra-high-molecular-weight carboxyl-terminated poly(D,L-lactide-co-glycolide) random copolymer with a 75:25 lactide-to-glycolide molar ratio. With substantially extended polymer chains compared to 40K and lower MW grades, this PLGA delivers exceptional tensile modulus, superior melt-processing performance and premium electrospinnability, featuring the slowest degradation kinetics within this 75:25 acid-capped PLGA portfolio. Retained reactive terminal carboxylic acid groups enable stable EDC/NHS-mediated bioconjugation with amine-functionalized peptides, antibodies and targeting ligands for fabricating functional biodegradable biomaterials. Its highly entangled, dense hydrophobic matrix effectively suppresses initial burst release and maintains structural integrity for extended periods, supporting predictable multi-month ultra-long sustained drug delivery. It is the premium candidate for thick three-dimensional electrospun nanofiber scaffolds, high-rigidity implantable depots, durable biodegradable barrier membranes and load-bearing tissue engineering constructs for advanced regenerative medicine research. Fully biocompatible, it degrades into non-toxic lactic acid and glycolic acid in vivo. Supplied as white amorphous powder; store sealed at -20°C under dry, dark environment to preserve molecular weight stability.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.