PLGA Acid Capped (PLGA-COOH, 75:25), MW 80K is a carboxyl-terminated poly(D,L-lactide-co-glycolide) copolymer. Its 75:25 lactide:glycolide composition and reactive COOH end group specifically support sustained drug delivery, bioconjugation, and functional polymer development.
Key Features and Benefits
- Acid Capped: Provides a terminal carboxylic acid group for conjugation and further functionalization.
- 75:25 PLGA Ratio: Higher lactide content supports controlled degradation and sustained drug release.
- MW 80K: Supports durable polymer matrices, practical processing, and sustained-release formulations.
- Reactive COOH Group: Supports amine coupling after activation with standard carbodiimide chemistry.
- Controlled Degradation: The lactide-rich composition supports extended hydrolytic degradation and sustained-release profiles.
- Biodegradable: PLGA hydrolyzes into lactic acid and glycolic acid under physiological conditions.
Applications
- Sustained Drug Delivery: Extends drug release through biodegradable polymer matrices.
- Bioconjugation: Enables attachment of peptides, proteins, targeting ligands, and other amine-containing molecules.
- Microparticles: Forms biodegradable microspheres and other sustained-release particle systems.
- Nanoparticles: Supports functional PLGA nanoparticles and biodegradable drug carriers.
- Polymer Modification: Provides a reactive COOH group for introducing linkers, ligands, and functional molecules.
Storage and Handling
- Storage: Store at –20 °C in a fully sealed container under dry and dark conditions.
- Handling: Protect from moisture, light, and excessive heat to maintain molecular weight and polymer performance.
This product combines higher molecular weight with reactive carboxyl functionality. Its lactide-rich composition specifically supports sustained drug delivery, bioconjugation, particle formulation, and functional biodegradable polymer development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.