Thiol-PEG-Azide (or Azide-PEG-Thiol) is a PEG-based linker with thiol (-SH) and azide (-N₃) groups. It is perfect for applications like click chemistry, bioconjugation, and surface modification.
Thiol-PEG-Azide
Thiol-PEG-Azide (or Azide-PEG-Thiol) is a heterobifunctional polyethylene glycol (PEG) linker with terminal thiol (-SH) and azide (-N₃) groups. Its design allows for versatile applications in bioconjugation and materials science.
Key Features:
- Functional Groups: Thiol (-SH) and azide (-N₃)
- PEG Spacer: Provides flexibility and improves solubility
- Solubility: Compatible with water, ethanol, chloroform, and DMSO
Applications:
- Click Chemistry:
- The azide group reacts with alkynes in click reactions to form stable triazoles.
- Bioconjugation:
- The thiol group enables reactions with maleimides or the formation of disulfide bonds for biomolecule attachment.
- Surface Modification:
- The thiol group binds to metal surfaces, such as gold, for functionalizing nanoparticles or biosensors.
Thiol-PEG-Azide is a versatile reagent for creating advanced molecular structures and functionalized surfaces.