Thiol-PEG1-Azide CAS:2179113-05-2 is a small molecule thiol linker that contains several functional groups, including a thiol group, a PEG (polyethylene glycol) chain, and an azide group.
The thiol group (-SH) is a sulfur-containing functional group that can react with other thiol groups or maleimide groups to form a stable covalent bond. Thiol groups are commonly used in bioconjugation and drug delivery to modify the surface of drugs or nanoparticles.
The PEG chain is a hydrophilic polymer that improves the solubility, stability, and biocompatibility of drugs or nanoparticles. PEG chains can also reduce the immunogenicity and toxicity of drugs, making them more suitable for clinical applications.
The azide group (-N3) is a nitrogen-containing functional group that can react with alkyne or cyclooctyne groups to form stable triazole linkages. This reaction is known as the Huisgen cycloaddition or “click” chemistry, and it is commonly used in bioconjugation and drug delivery to attach small molecules or peptides to larger biomolecules. See other thiol peg azide.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.