DMPA
Full Name: 1,2-Dimyristoyl-sn-glycero-3-phosphate (sodium salt)
CAS No.: 80724-31-8
Key Properties
- An anionic phospholipid containing two saturated myristic acid (C14:0) fatty acyl chains and a negatively charged phosphate head group.
- Negatively charged at physiological pH, enabling electrostatic interaction with cationic lipids or proteins.
- High bilayer-forming stability and good biocompatibility.
- Improves the stability of lipid assemblies and enhances nucleic acid encapsulation in cationic lipid formulations.
- Practically insoluble in water; soluble in chloroform, methanol, and other organic solvents.
- Usually supplied as a white to off-white powder or solid.
- Storage: −20 °C, desiccated and protected from light.
Applications
- Used as a helper lipid in liposome and lipid nanoparticle (LNP) formulations for gene and nucleic acid delivery.
- Enhances encapsulation efficiency of negatively charged nucleic acids (DNA, mRNA, siRNA) in cationic lipid systems.
- Stabilizes lipid bilayers and improves the colloidal stability of nanoparticles.
- Used in the preparation of pH-sensitive liposomes and targeted drug delivery systems.
- Applied in vaccine delivery systems and non-viral gene therapy vectors.
- Used as a model lipid in biomembrane research and liposome characterization studies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
