DSPE-Succinic Acid (DSPE-COOH) is a carboxyl-functionalized phospholipid derivative featuring a hydrophobic DSPE lipid anchor and terminal carboxylic acid functionality. The carboxyl group provides an especially versatile site for conjugation, surface modification, and functional lipid research.
Key Features and Benefits
- Carboxyl-Functionalized Phospholipid: DSPE-Succinic Acid (DSPE-COOH) provides accessible carboxylic acid functionality for further modification.
- DSPE Lipid Anchor: DSPE contains two saturated C18 stearoyl chains that support incorporation into compatible lipid membranes and assemblies.
- Carboxyl Functionality: The terminal COOH group provides a reactive site for coupling with amine-containing molecules after suitable activation.
- Amine Coupling: Activated carboxyl groups can react with primary amines to form stable amide bonds.
- EDC/NHS Chemistry: The carboxyl group supports commonly used carbodiimide-mediated coupling strategies, including EDC/NHS activation.
- Amphiphilic Character: The lipid structure specifically supports incorporation into compatible liposomes, nanoparticles, and membrane systems.
- Surface Functionalization: DSPE-COOH provides carboxyl functionality at lipid interfaces for subsequent chemical modification.
- Functional Lipid Platform: The combination of a DSPE anchor and carboxyl group specifically supports diverse bioconjugation and biomaterial applications.
Applications
- Bioconjugation: DSPE-Succinic Acid (DSPE-COOH) provides carboxyl groups for coupling with compatible amine-containing molecules.
- Ligand Conjugation: Supports attachment of peptides, proteins, probes, and other amine-containing ligands after suitable activation.
- Liposome Functionalization: Enables incorporation of carboxyl-functionalized lipids into compatible liposome systems.
- Lipid Nanoparticle Research: Provides functional lipid components for experimental lipid nanoparticle formulations.
- Nanoparticle Functionalization: Supports introduction of reactive carboxyl groups onto compatible lipid-containing nanoparticles.
- Surface Modification: Provides COOH functionality for further modification of lipid and material interfaces.
- Lipid Conjugate Synthesis: Serves as a functional phospholipid building block for preparing modified lipid conjugates.
- Biomaterial Research: Supports development of functional lipid assemblies, surfaces, and biomaterial systems.
Storage and Handling
- Storage: Store according to the product specification in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
DSPE-Succinic Acid (DSPE-COOH) combines a hydrophobic DSPE lipid anchor with reactive carboxylic acid functionality and specificallyh provides a versatile platform for amine coupling, bioconjugation, lipid functionalization, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
