DMPC

Key Properties

• A neutral, saturated phospholipid containing two myristic acid (C14:0) acyl chains and a phosphocholine head group.
• Forms stable, tightly packed lipid bilayers with well-defined phase transition behavior.
• Biocompatible, non-toxic, and highly stable in aqueous environments.
• Near-zero net charge at physiological pH, minimizing nonspecific interactions.
• Moderately hydrophobic; soluble in chloroform, methanol, and ethanol; dispersible in water to form liposomes.
• Typically a white to off-white crystalline powder.
• Storage: −20 °C, desiccated and protected from light.

Applications

• Widely used as a structural helper lipid in liposomes, lipid nanoparticles (LNPs), and micelles.
• Serves as a standard model lipid for studying biomembrane structure, dynamics, and interactions.
• Improves bilayer stability and uniformity in drug delivery systems.
• Used in vaccine formulations, gene delivery vectors, and cosmetic liposome products.
• Applied in membrane protein reconstitution and structural biology research.
• Used to prepare long-circulating, biocompatible carriers for small-molecule drugs and nucleic acids.