DPPA
Full Name: 1,2-Dipalmitoyl-sn-glycero-3-phosphate (sodium salt)
CAS No.: 169051-60-9
Key Properties
- An anionic phospholipid with two saturated palmitic acid (C16:0) chains and a negatively charged phosphate head group.
- Negatively charged at physiological pH, enabling strong electrostatic interactions with cationic lipids, proteins, and nucleic acid complexes.
- High thermal and structural stability, forming stable lamellar bilayer structures.
- Improves colloidal stability of lipid nanoparticles and liposomal formulations.
- Practically insoluble in water; soluble in organic solvents such as chloroform, methanol, and DMSO.
- Usually appears as a white to off-white powder or solid.
- Stable under dry conditions; recommended storage at −20 °C, protected from light and moisture.
Applications
- Used as an anionic helper lipid in liposomes and lipid nanoparticles (LNPs) for nucleic acid delivery.
- Enhances encapsulation efficiency of DNA, mRNA, siRNA, and other negatively charged payloads.
- Improves stability and membrane integrity of lipid-based delivery systems.
- Applied in vaccine formulations, gene delivery vectors, and non-viral gene therapy systems.
- Used as a model lipid in biomembrane research and liposome characterization.
- Suitable for pH-responsive and targeted liposomal drug delivery systems.
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