PCL-PEG-OPSS, MW x 1K, n 3K is a thiol-reactive amphiphilic block copolymer. It combines a 1K poly(ε-caprolactone) (PCL) block with a 3K polyethylene glycol (PEG) block. Its PEG-rich architecture supports hydrophilic stabilization and surface functionality while the terminal OPSS group enables thiol-selective conjugation through disulfide bond formation.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG for polymer assembly and functional drug delivery.
- PCL MW 1K: Provides a short biodegradable hydrophobic segment for polymer assembly and hydrophobic interactions.
- PEG MW 3K: Provides a dominant hydrophilic segment specifically for aqueous compatibility and steric stabilization.
- PEG-Rich Architecture: The 3:1 PEG-to-PCL molecular weight ratio favors hydrophilic character and surface stabilization.
- OPSS Functionalization: Provides an orthopyridyl disulfide group for esepecially selective reaction with free thiols.
- Thiol-Reactive: OPSS undergoes disulfide exchange with sulfhydryl groups to form disulfide-linked conjugates.
Applications
- Bioconjugation: Enables attachment of thiol-containing peptides, proteins, and other biomolecules.
- Nanoparticle Functionalization: Supports PEG-rich surfaces and ligand-functionalized polymeric nanocarriers.
- Drug Delivery: Supports functionalized amphiphilic carriers and targeted drug delivery research.
- Ligand Conjugation: Enables attachment of thiolated targeting ligands specifically through cleavable disulfide linkages.
- Redox-Responsive Systems: Supports development of reduction-sensitive polymer conjugates and biomaterial systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture, excessive heat, and reducing agents to preserve OPSS functionality.
PCL-PEG-OPSS, MW x 1K, n 3K combines a short PCL block with a longer PEG segment and thiol-reactive OPSS and specifically supports hydrophilic stabilization, disulfide conjugation, nanocarrier functionalization, and redox-responsive biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.