PCL-PEG-OPSS, MW x 2K, n 3K is a thiol-reactive amphiphilic block copolymer. It combines a 2K poly(ε-caprolactone) (PCL) block with a 3K polyethylene glycol (PEG) block, and its PEG-rich architecture supports hydrophilic stabilization, while the terminal OPSS group enables thiol-selective disulfide conjugation.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG for polymer assembly and drug delivery.
- PCL MW 2K: Provides a biodegradable hydrophobic segment for polymer assembly and hydrophobic drug incorporation.
- PEG MW 3K: Provides a longer hydrophilic segment for aqueous compatibility and steric stabilization.
- PEG-Rich Architecture: The 3:2 PEG-to-PCL ratio favors hydrophilic stabilization while retaining amphiphilic behavior.
- OPSS Functionalization: Provides a terminal orthopyridyl disulfide group that selectively reacts with free thiols.
- Disulfide Formation: OPSS undergoes thiol-disulfide exchange to form reduction-cleavable disulfide-linked conjugates.
Applications
- Bioconjugation: Enables attachment of thiol-containing peptides, proteins, and other biomolecules.
- Nanoparticle Functionalization: Supports ligand-functionalized nanoparticles, micelles, and polymeric nanocarriers.
- Drug Delivery: Supports amphiphilic carriers for hydrophobic compounds and targeted delivery research.
- Ligand Conjugation: Enables attachment of thiolated targeting ligands through disulfide linkages.
- Redox-Responsive Systems: Supports reduction-sensitive polymer conjugates and functional biomaterial systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture, excessive heat, and reducing agents to preserve OPSS functionality.
PCL-PEG-OPSS, MW x 2K, n 3K combines a PEG-rich architecture with thiol-reactive OPSS functionality and specifically supports disulfide conjugation, nanocarrier functionalization, targeted drug delivery, and redox-responsive biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.