PCL-PEG-OPSS, MW x 3K, n 2K is a thiol-reactive amphiphilic block copolymer. It combines a 3K poly(ε-caprolactone) (PCL) block with a 2K polyethylene glycol (PEG) block, and its moderately PCL-rich architecture supports hydrophobic core formation and drug incorporation, while the terminal OPSS group enables thiol-selective conjugation through disulfide exchange.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG for polymer assembly and drug delivery.
- PCL MW 3K: Provides a biodegradable hydrophobic segment for core formation and incorporation of hydrophobic compounds.
- PEG MW 2K: Provides a hydrophilic segment specifically for aqueous compatibility and interfacial stabilization.
- PCL-Rich Architecture: The 3:2 PCL-to-PEG molecular weight ratio favors hydrophobic interactions while retaining PEG-mediated stabilization.
- OPSS Functionalization: Provides a terminal orthopyridyl disulfide group that selectively reacts with free thiols.
- Disulfide Formation: OPSS undergoes thiol-disulfide exchange to form covalent, reduction-cleavable disulfide-linked conjugates.
Applications
- Bioconjugation: Enables attachment of thiol-containing peptides, proteins, and other biomolecules.
- Nanoparticle Functionalization: Supports ligand-functionalized nanoparticles, micelles, and polymeric assemblies.
- Drug Delivery: Supports hydrophobic drug incorporation and functionalized polymeric carrier development.
- Ligand Conjugation: Enables attachment of thiolated targeting ligands through disulfide linkages.
- Redox-Responsive Systems: Supports reduction-sensitive polymer conjugates and biomaterial systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture, excessive heat, and reducing agents to preserve OPSS functionality.
PCL-PEG-OPSS, MW x 3K, n 2K combines a moderately PCL-rich amphiphilic architecture with thiol-reactive OPSS functionality and specifically supports hydrophobic drug incorporation, disulfide conjugation, nanoparticle functionalization, and redox-responsive biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.