PCL-PEG-OPSS, MW x 5K, n 5K is a thiol-reactive amphiphilic block copolymer. It combines a 5K poly(ε-caprolactone) block with a 5K polyethylene glycol block. Its balanced architecture supports amphiphilic assembly and surface functionalization while the terminal OPSS group enables thiol-selective conjugation through disulfide bond formation.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG for polymer assembly and drug delivery.
- PCL MW 5K: Provides a biodegradable hydrophobic segment for core formation and hydrophobic drug incorporation.
- PEG MW 5K: Provides a hydrophilic segment specifically for aqueous compatibility and steric stabilization.
- Balanced Block Ratio: Equal PCL and PEG molecular weights provide especially balanced hydrophobic and hydrophilic character.
- OPSS Functionalization: Provides an orthopyridyl disulfide group for selective reaction with free thiols.
- Thiol-Reactive: OPSS undergoes disulfide exchange with sulfhydryl groups to form disulfide-linked conjugates.
Applications
- Bioconjugation: Enables attachment of thiol-containing peptides, proteins, and other biomolecules.
- Nanoparticle Functionalization: Supports ligand-functionalized nanoparticles, micelles, and amphiphilic polymer assemblies.
- Drug Delivery: Supports functionalized polymeric carriers and targeted drug delivery research.
- Ligand Conjugation: Enables attachment of thiolated targeting ligands through cleavable disulfide linkages.
- Redox-Responsive Systems: Supports development of reduction-sensitive polymer conjugates and biomaterial systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture, excessive heat, and reducing agents to preserve OPSS functionality.
PCL-PEG-OPSS, MW x 5K, n 5K combines balanced PCL and PEG blocks with thiol-reactive OPSS functionality and specifically supports amphiphilic assembly, disulfide conjugation, targeted drug delivery, and redox-responsive biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.