PCL-PEG-OPSS, MW x 4K, n 1K is a thiol-reactive amphiphilic block copolymer. It combines a 4K poly(ε-caprolactone) (PCL) block with a 1K polyethylene glycol (PEG) block, and its strongly PCL-rich architecture supports hydrophobic core formation and drug incorporation, while the terminal OPSS group enables thiol-selective conjugation through disulfide exchange.
Key Features and Benefits
- Amphiphilic Copolymer: Combines a dominant hydrophobic PCL block with a short hydrophilic PEG segment.
- PCL MW 4K: Provides a biodegradable hydrophobic segment for core formation and incorporation of hydrophobic compounds.
- PEG MW 1K: Provides a short hydrophilic segment specifically for interfacial stabilization and surface functionality.
- PCL-Rich Architecture: The 4:1 PCL-to-PEG molecular weight ratio favors hydrophobic interactions and core-forming assemblies.
- OPSS Functionalization: Provides a terminal orthopyridyl disulfide group that selectively reacts with free thiols.
- Disulfide Formation: OPSS undergoes thiol-disulfide exchange to form covalent, reduction-cleavable disulfide-linked conjugates.
Applications
- Bioconjugation: Enables attachment of thiol-containing peptides, proteins, and other biomolecules.
- Nanoparticle Functionalization: Supports ligand-functionalized nanoparticles, micelles, and polymeric assemblies.
- Drug Delivery: Supports hydrophobic drug incorporation and functionalized polymeric carrier development.
- Ligand Conjugation: Enables attachment of thiolated targeting ligands through disulfide linkages.
- Redox-Responsive Systems: Supports reduction-sensitive polymer conjugates and biomaterial systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture, excessive heat, and reducing agents to preserve OPSS functionality.
PCL-PEG-OPSS, MW x 4K, n 1K combines a strongly PCL-rich architecture with thiol-reactive OPSS functionality that specifically supports hydrophobic drug incorporation, disulfide conjugation, nanoparticle functionalization, and redox-responsive biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.