Biotin‑Poly(ε‑caprolactone) (PCL‑biotin), MW 5K is a medium‑molecular‑weight, biotin‑terminated biodegradable poly(ε‑caprolactone) polymer covalently functionalized with terminal biotin moiety for high‑affinity avidin/streptavidin‑mediated bioconjugation. Featuring moderate structural rigidity, balanced crystallinity, good organic solubility, and medium‑rate hydrolytic degradation kinetics relative to lower‑ and higher‑MW PCL analogs, this hydrophobic biotin‑tagged polymer retains robust biotin‑streptavidin binding performance. It acts as a versatile functional building block for biotin‑decorated nanoparticle fabrication, medium‑cycle targeted drug delivery, avidin‑driven biomolecule immobilization, and affinity‑based biomedical biosensor development.
Key Features:
- Medium‑molecular‑weight semi‑crystalline poly(ε‑caprolactone) backbone with covalently coupled terminal biotin end‑group
- Strong, specific binding affinity towards avidin and streptavidin for affinity‑driven bioconjugation workflows
- Good solubility in DCM, chloroform, THF and other common anhydrous organic lab‑grade solvents
- Moderate hydrolytic degradation profile suitable for medium‑term in vitro and in vivo research studies
- Defined end‑group functionality, low residual monomer and catalyst content for biomedical experimental applications
Applications:
- Biotin‑functionalized polymeric nanoparticles, micelles, and electrospun nanofiber scaffolds
- Avidin‑streptavidin mediated targeted drug‑delivery carrier construction
- Affinity‑oriented biomolecule immobilization and biosensor surface functionalization
- Medium‑term biodegradable polymer carriers for biological and pharmacokinetic evaluation
- Fabrication of biotin‑labeled polymer‑biomolecule hybrid bioconjugates
Handling & Storage: Store at −20 °C under dry, inert atmosphere; avoid moisture ingress and repeated freeze‑thaw cycles. Equilibrate the polymer to ambient temperature inside a desiccator prior to opening the container. Dissolve using anhydrous organic solvents under dry conditions. For research‑only use; not intended for human clinical administration.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.