Biotin‑Poly(ε‑caprolactone) (PCL‑biotin), MW 3K is a low‑to‑medium‑molecular‑weight, biotin‑terminated biodegradable poly(ε‑caprolactone) polymer covalently modified with terminal biotin moiety for high‑affinity avidin/streptavidin‑driven bioconjugation. Featuring mild structural rigidity, favorable organic solubility, and intermediate hydrolytic degradation kinetics falling between 2 K and 5 K PCL‑biotin grades, this hydrophobic biotin‑labelled polymer maintains reliable biotin‑streptavidin binding activity. It serves as a practical functional building block for biotin‑decorated nanoparticle preparation, intermediate‑cycle targeted drug delivery, avidin‑assisted biomolecule immobilization, and affinity‑based biomedical assay construction.
Key Features:
- Low‑to‑medium‑molecular‑weight semi‑crystalline poly(ε‑caprolactone) backbone with covalently attached terminal biotin end‑group
- High specific binding affinity against avidin and streptavidin to support affinity‑mediated bioconjugation workflows
- Good solubility in DCM, chloroform, THF and other typical anhydrous organic solvents for polymer processing
- Intermediate degradation rate, well‑suited for intermediate‑term in vitro and in vivo experimental investigations
- Controlled end‑group functionality, low residual catalyst and monomer content for biomedical laboratory‑scale research
Applications:
- Biotin‑functionalized nanoparticles, polymeric micelles and electrospun nanofiber constructs
- Avidin‑streptavidin guided targeted drug delivery system prototyping
- Affinity‑based biomolecule immobilization and biosensor surface modification
- Intermediate‑term biodegradable carriers for biological and preliminary pharmacokinetic studies
- Assembly of biotin‑tagged polymer‑biomolecule hybrid conjugates
Handling & Storage: Store at −20 °C under dry, inert atmosphere; prevent moisture exposure and repeated freeze‑thaw cycles. Allow the polymer to reach room temperature within a desiccator before opening the vessel. Perform dissolution with anhydrous organic solvents under dry conditions. For research‑only use, not for human clinical application.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.