Biotin‑Poly(ε‑caprolactone) (PCL‑biotin), MW 15K is a high‑molecular‑weight, biotin‑terminated biodegradable poly(ε‑caprolactone) polymer covalently functionalized with terminal biotin moiety for high‑affinity avidin/streptavidin‑mediated bioconjugation. Featuring boosted structural rigidity, pronounced crystallinity, acceptable organic solubility, and extended‑to‑ultra‑prolonged hydrolytic degradation kinetics positioned between 10 K and 20 K PCL‑biotin grades, this hydrophobic biotin‑tagged polymer retains stable long‑lasting biotin‑streptavidin binding activity. It serves as a high‑grade functional building block for biotin‑decorated nanoparticle and scaffold fabrication, prolonged‑cycle targeted drug delivery, avidin‑assisted biomolecule immobilization, and affinity‑based biomedical biosensor development.
Key Features:
- High‑molecular‑weight semi‑crystalline poly(ε‑caprolactone) backbone with covalently coupled terminal biotin end‑group
- Reliable high‑specific binding affinity toward avidin and streptavidin for durable affinity‑driven bioconjugation workflows
- Acceptable solubility in DCM, chloroform, THF and other anhydrous organic solvents under standard polymer‑processing conditions
- Intermediate‑slow hydrolytic degradation profile suited for prolonged multi‑week to early‑multi‑month in vitro and in vivo pre‑clinical studies
- Well‑defined end‑group functionality, low residual monomer and catalyst content for advanced biomedical laboratory‑scale research
Applications:
- Biotin‑functionalized polymeric nanoparticles, micelles, and electrospun nanofiber scaffolds
- Avidin‑streptavidin mediated prolonged‑acting targeted drug‑delivery carrier construction
- Affinity‑oriented biomolecule immobilization and biosensor surface functionalization
- Prolonged‑term biodegradable polymer carriers for biological and pharmacokinetic evaluation
- Fabrication of biotin‑labeled polymer‑biomolecule hybrid bioconjugates for intermediate implant‑related research
Handling & Storage: Store at −20 °C under dry, inert atmosphere; avoid moisture ingress and repeated freeze‑thaw cycles. Equilibrate the polymer to ambient temperature inside a desiccator prior to opening the container. Dissolve using anhydrous organic solvents under dry conditions. For research‑only use; not intended for human clinical administration.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.