Biotin‑Poly(ε‑caprolactone) (PCL‑biotin), MW 10K is a high‑molecular‑weight, biotin‑terminated biodegradable poly(ε‑caprolactone) polymer covalently functionalized with terminal biotin moiety for high‑affinity avidin/streptavidin‑mediated bioconjugation. Featuring enhanced structural rigidity, elevated crystallinity, good organic solubility, and prolonged hydrolytic degradation kinetics compared with lower‑MW PCL‑biotin variants, this hydrophobic biotin‑tagged polymer preserves stable biotin‑streptavidin binding capacity. It acts as a high‑performance functional building block for biotin‑decorated nanoparticle manufacturing, long‑cycle targeted drug delivery, avidin‑mediated biomolecule immobilization, and affinity‑based biomedical biosensor development.
Key Features:
- High‑molecular‑weight semi‑crystalline poly(ε‑caprolactone) backbone with covalently coupled terminal biotin end‑group
- Stable high‑specific binding affinity toward avidin and streptavidin for long‑term affinity‑driven bioconjugation workflows
- Acceptable solubility in DCM, chloroform, THF and other anhydrous organic solvents under standard polymer‑processing conditions
- Extended hydrolytic degradation profile suitable for long‑term in vitro and in vivo pre‑clinical research
- Well‑defined end‑group functionality, low residual monomer and catalyst content for biomedical experimental applications
Applications:
- Biotin‑functionalized polymeric nanoparticles, micelles, and electrospun nanofiber scaffolds
- Avidin‑streptavidin mediated long‑acting targeted drug‑delivery carrier construction
- Affinity‑oriented biomolecule immobilization and biosensor surface functionalization
- Long‑term biodegradable polymer carriers for biological and pharmacokinetic evaluation
- Fabrication of biotin‑labeled polymer‑biomolecule hybrid bioconjugates
Handling & Storage: Store at −20 °C under dry, inert atmosphere; avoid moisture ingress and repeated freeze‑thaw cycles. Equilibrate the polymer to ambient temperature inside a desiccator prior to opening the container. Dissolve using anhydrous organic solvents under dry conditions. For research‑only use; not intended for human clinical administration.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.