Biotin‑Poly(ε‑caprolactone) (PCL‑biotin), MW 2K is a low‑molecular‑weight, biotin‑terminated biodegradable poly(ε‑caprolactone) polymer functionalized with terminal biotin moiety for high‑affinity avidin/streptavidin bioconjugation. Featuring low structural rigidity, excellent organic solubility, and relatively fast hydrolytic degradation profile compared with higher‑molecular‑weight PCL analogs, this biotin‑labeled hydrophobic polymer retains high‑specific biotin‑binding activity. It serves as a functional building block for biotin‑decorated nanoparticle fabrication, short‑term targeted drug delivery, avidin‑mediated biomolecule immobilization, and affinity‑based biomedical assay development.
Key Features:
- Low‑molecular‑weight hydrophobic poly(ε‑caprolactone) backbone with covalently attached terminal biotin group
- High binding affinity toward avidin and streptavidin for affinity‑mediated bioconjugation
- Excellent solubility in DCM, chloroform, THF and other common organic solvents
- Relatively fast hydrolytic degradation kinetics for short‑term in vitro and in vivo studies
- Well‑defined end‑group functionality, low residual catalyst and monomer content for biomedical research
Applications:
- Biotin‑functionalized polymeric nanoparticles, micelles and electrospun nanofibers
- Avidin‑streptavidin mediated targeted drug delivery systems
- Affinity‑based biomolecule immobilization and biosensor surface modification
- Short‑term biodegradable carrier for in‑vitro biological evaluation
- Construction of biotin‑labeled polymer‑biomolecule hybrid conjugates
Handling & Storage: Store at −20 °C under dry, inert atmosphere; avoid moisture exposure and repeated freeze‑thaw cycles. Equilibrate polymer to room‑temperature in desiccator before opening container. Dissolve in anhydrous organic solvents under dry conditions. For research‑only use, not for human clinical administration.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
