Biotin‑Poly(ε‑caprolactone) (PCL‑biotin), MW 20K is an ultra‑high‑molecular‑weight, biotin‑terminated biodegradable poly(ε‑caprolactone) polymer covalently functionalized with terminal biotin moiety for high‑affinity avidin/streptavidin‑mediated bioconjugation. Featuring ultra‑enhanced structural rigidity, high crystallinity, satisfactory organic solubility, and ultra‑prolonged multi‑month hydrolytic degradation kinetics relative to lower‑molecular‑weight PCL‑biotin grades, this hydrophobic biotin‑tagged polymer maintains durable biotin‑streptavidin binding performance. It serves as a premium functional building block for biotin‑decorated implant‑grade nanoparticle fabrication, ultra‑long‑cycle targeted drug delivery, avidin‑driven biomolecule immobilization, and affinity‑based biomedical biosensor development.
Key Features:
- Ultra‑high‑molecular‑weight semi‑crystalline poly(ε‑caprolactone) backbone with covalently coupled terminal biotin end‑group
- Durable high‑specific binding affinity towards avidin and streptavidin for long‑term affinity‑mediated bioconjugation workflows
- Satisfactory solubility in DCM, chloroform, THF and other anhydrous organic solvents under appropriate polymer‑processing conditions
- Ultra‑slow hydrolytic degradation profile optimized for multi‑month in vitro and in vivo pre‑clinical research
- Well‑defined end‑group functionality, low residual monomer and catalyst content for advanced biomedical experimental applications
Applications:
- Biotin‑functionalized polymeric nanoparticles, micelles, and implantable electrospun nanofiber scaffolds
- Avidin‑streptavidin mediated ultra‑long‑acting targeted drug‑delivery carrier construction
- Affinity‑oriented biomolecule immobilization and biosensor surface functionalization
- Multi‑month long‑term biodegradable polymer carriers for biological and pharmacokinetic evaluation
- Fabrication of biotin‑labeled polymer‑biomolecule hybrid bioconjugates for implant‑relevant studies
Handling & Storage: Store at −20 °C under dry, inert atmosphere; avoid moisture ingress and repeated freeze‑thaw cycles. Equilibrate the polymer to ambient temperature inside a desiccator prior to opening the container. Dissolve using anhydrous organic solvents under dry conditions. For research‑only use; not intended for human clinical administration.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.