M-PEG-(CH2)-phosphonic acid contains a phosphonic acid functional group (-PO3H2) attached to the PEG chain through a methylene (-CH2-) linker.
The phosphonic acid group provides M-PEG-(CH2)-phosphonic acid with unique properties, making it an attractive candidate for use in pharmaceutical research and development. This functional group is known for its ability to chelate metal ions, such as calcium, magnesium, and zinc, forming stable complexes that can have a variety of biological effects.
In drug delivery, M-PEG-(CH2)-phosphonic acid has been utilized as a surface modifier for nanoparticles and liposomes. The phosphonic acid group can chelate calcium ions present in the extracellular matrix, resulting in a charge reversal on the particle surface and an increase in cellular uptake. Additionally, this compound has been explored as a bone-targeting agent due to its ability to bind to hydroxyapatite, a mineral present in bone tissue.