M-PEG-phosphonic acid contains a phosphonic acid functional group (-PO3H2) attached to the middle carbon atom of a PEG chain. The phosphonic acid group is known for its ability to interact with calcium ions and form stable complexes, making M-PEG-phosphonic acid a useful tool in the field of pharmaceutical research and development.
M-PEG-phosphonic acid has been extensively utilized in the development of novel drug delivery systems, especially for bone-targeted therapies. Its unique chemical properties allow for the formation of stable complexes with calcium ions in bones, leading to selective accumulation and sustained release of therapeutic agents in bone tissues. This targeted approach enhances therapeutic efficacy while minimizing systemic toxicity.
In addition to bone-targeted drug delivery systems, M-PEG-phosphonic acid has also been employed as a surface modifier in various biomedical applications. For example, it can be immobilized onto the surface of implants to improve osseointegration and reduce implant failure.