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PEG-bis(phosphonic acid) is a polyethylene glycol (PEG) derivative that contains two phosphonic acid (-PO3H2) functional groups attached to the PEG backbone.

The phosphonic acid functional group is known for its ability to bind to hydroxyapatite, the main mineral component of bone tissue. This property has made PEG-bis(phosphonic acid) a promising candidate for the development of bone-targeting drug delivery systems. By conjugating therapeutic agents to the PEG chain via a linker, such as a disulfide bond or a cleavable ester bond, the resulting conjugates can selectively accumulate in bone tissue, leading to enhanced therapeutic efficacy and reduced systemic toxicity.

PEG-bis(phosphonic acid)

Cat# Name Structure M.W. Purity Pricing
AP11786PEG2-bis(phosphonic acid)278.13≥95% Pricing
AP11787PEG3-bis(phosphonic acid)322.19≥95% Pricing

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