VH-298 is an E3 ubiquitin ligase, a potent and selective VHL inhibitor (Kd value of 80-90 nM), VH298 acts on the downstream of PHD enzyme, it can effectively destroy the interaction between VHL and hypoxia-inducible factor HIF-α Interaction, upregulates the mRNA and protein levels of HIF target genes, resulting in a transcriptional signature similar to hypoxia.
VH-298
| Cat# | Name | Structure | Pricing |
|---|---|---|---|
| AP14678 | VH-298 | Pricing |
